The Science

Over the last decade,

the research is clear and compelling:


Cognitive decline can be reversed and Alzheimer’s may be prevented through personalized, multi-domain, Functional Medicine, & lifestyle programs.


Members of our team have contributed to this research and we have designed our programs to include the most effective approaches and solutions from these groundbreaking works.

We will continue to partner with many of the leaders below to reinforce the data and help reach more people in need of effective solutions. Without their contributions we would not be here today. 

Individualized clinical management of
patients at risk for Alzheimer’s dementia
Dr. Richard Isaacson,
Alzheimer's & Dementia
Full Text Link
Isaccson Paper


  • 174 Participants were classified as Mild Cognitive Impairment (MCI) or “at risk” (normal cognitive function or subjective cognitive decline).

  • Outcomes measured were cognitive test scores, and health biomarkers that are correlated with cognitive decline.

  • A personalized, precision medical and lifestyle program was given to each participant. 


The results: Both groups that demonstrated greater than 60% compliance performed better than the control group (no treatment). The surprise - “at-risk” participants with <60% compliance still performed better than the control group!  The MCI participants with low compliance did no better than the control group.

Reversal of Cognitive Decline: 100 Patients
Dr. Dale Bredesen,
Journal of Alzheimer's Disease & Parkinsonism
Full Text Link
Bredesen Paper


Building off of Dr. Bredesen's first two publications, and his best selling book, The End of Alzheimer's, this paper describes 100 cognitive decline reversal case studies collected from 16 different clinics. Each clinic used a multi-domain approach including Functional Medicine and lifestyle modification. Condition severity and root causes were different within the population. Pre and Post data was tracked for each case.

The results: 100 individuals with varying degrees of cognitive decline showed improvement in their brain function, cognitive decline symptoms and overall quality of life

Note: Seth Conger (MIOS Health CEO) was a contributor to this paper

A Personalized 12-week “Brain Fitness Program” for Improving Cognitive Function and Increasing the Volume of Hippocampus in Elderly with Mild Cognitive Impairment
Dr. Majid Fotuhi,
The Journal of Prevention of Alzheimer's Disease
Full Text Link
Fotuhi Paper


127 patients with diagnosed Mild Cognitive Impairment (MCI), participated in a 12-week multi-domain program including precision medical treatment and lifestyle modification. This is still the largest study to date to specifically look at brain function improvement in a MCI population. 


The Results: 84% of the patients saw statistically significant improvements in their brain function. Also, a random sample of patients who had pre-post volumetric MRI showed no atrophy or actual growth of the hippocampus which plays a major role in memory creation and storage.

The FINGER Study
Full Text Link


The largest study to date looking at modifiable vascular and lifestyle-related risk factors which have been associated with dementia risk. A double-blind, randomized controlled trial with 2654 individuals aged 60-77. The 2-year intervention group received a multi-domain intervention while the control group received general health advice only.


The Results: A multi-domain intervention can improve or maintain cognitive functioning in at-risk elderly people.

Looking for more?

We've taken the complex science and broken it down into bite-size, simple videos that make sense.