174 Participants were classified as Mild Cognitive Impairment (MCI) or “at risk” (normal cognitive function or subjective cognitive decline).
Outcomes measured were cognitive test scores, and health biomarkers that are correlated with cognitive decline.
A personalized, precision medical and lifestyle program was given to each participant.
The results: Both groups that demonstrated greater than 60% compliance performed better than the control group (no treatment). The surprise - “at-risk” participants with <60% compliance still performed better than the control group! The MCI participants with low compliance did no better than the control group.
Building off of Dr. Bredesen's first two publications, and his best selling book, The End of Alzheimer's, this paper describes 100 cognitive decline reversal case studies collected from 16 different clinics. Each clinic used a multi-domain approach including Functional Medicine and lifestyle modification. Condition severity and root causes were different within the population. Pre and Post data was tracked for each case.
The results: 100 individuals with varying degrees of cognitive decline showed improvement in their brain function, cognitive decline symptoms and overall quality of life
Note: Seth Conger (MIOS Health CEO) was a contributor to this paper
A Personalized 12-week “Brain Fitness Program” for Improving Cognitive Function and Increasing the Volume of Hippocampus in Elderly with Mild Cognitive Impairment
127 patients with diagnosed Mild Cognitive Impairment (MCI), participated in a 12-week multi-domain program including precision medical treatment and lifestyle modification. This is still the largest study to date to specifically look at brain function improvement in a MCI population.
The Results: 84% of the patients saw statistically significant improvements in their brain function. Also, a random sample of patients who had pre-post volumetric MRI showed no atrophy or actual growth of the hippocampus which plays a major role in memory creation and storage.
The largest study to date looking at modifiable vascular and lifestyle-related risk factors which have been associated with dementia risk. A double-blind, randomized controlled trial with 2654 individuals aged 60-77. The 2-year intervention group received a multi-domain intervention while the control group received general health advice only.
The Results: A multi-domain intervention can improve or maintain cognitive functioning in at-risk elderly people.
Looking for more?
We've taken the complex science and broken it down into bite-size, simple videos that make sense.